Arby: automatic protein structure prediction using profile-profile alignment and confidence measures

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Arby: automatic protein structure prediction using profile-profile alignment and confidence measures

MOTIVATION Arby is a new server for protein structure prediction that combines several homology-based methods for predicting the three-dimensional structure of a protein, given its sequence. The methods used include a threading approach, which makes use of structural information, and a profile-profile alignment approach that incorporates secondary structure predictions. The combination of the d...

متن کامل

Profile-Profile Alignment: A Powerful Tool for Protein Structure Prediction

The problem of computing the tertiary structure of a protein from a given amino acid sequence has been a major subject of bioinformatics research during the last decade. Many different approaches have been taken to tackle the problem, the most successful of which are based on searching databases to identify a similar amino acid sequence in the PDB and using the corresponding structure as a temp...

متن کامل

Automatic Phonetic Alignment and Its Confidence Measures

In this paper we propose the use of an HMM-based phonetic aligner together with a speech-synthesis-based one to improve the accuracy of the global alignment system. We also present a phone durationindependent measure to evaluate the accuracy of the automatic annotation tools. In the second part of the paper we propose and evaluate some new confidence measures for phonetic annotation.

متن کامل

Protein Structure Alignment through a Contact Topology Profile using SABERTOOTH

The contact vector (CV) of a protein structure is one of the simplest and most condensed descriptions of protein structure available. It lists the number of contacts each amino acid has with the surrounding structure and has frequently been used e.g. to derive approximative folding energies in protein folding analysis. The CV, however, is a lossy structure representation, as it does not contain...

متن کامل

115. The Arby Automated Protein Structure Prediction Server

The method starts by constructing a set of subsequences from the query sequence, each subsequence representing a hypothesis for a possible protein domain. This is done by scanning against the InterPro database and using hits as domain hypotheses [1]. Additional hypotheses are constructed using a secondary structure prediction from PSIPRED [2]. Segments of predicted loops are used as potential d...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bioinformatics

سال: 2004

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/bth232